The enzyme tagatose-bisphosphate aldolase (EC 4.1.2.40) catalyzes the chemical reaction

D-tagatose 1,6-bisphosphate glycerone phosphate^[1] + Dglyceraldehyde 3-phosphate

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is D-tagatose 1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming). This enzyme is also called D-tagatose-1,6-bisphosphate triosephosphate lyase. This enzyme participates in galactose metabolism.

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GVF.

• Anderson RL, Markwell JP (1982). "D-Tagatose-1,6-bisphosphate aldolase (Class II) from Klebsiella pneumoniae". Carbohydrate Metabolism - Part E. Methods Enzymol. Vol. 90. pp. 323–324. doi:10.1016/s0076-6879(82)90131-8. ISBN 978-0-12-181990-3. PMID 6759854.
• van Rooijen RJ, van Schalkwijk S, de Vos WM (1991). "Molecular cloning, characterization, and nucleotide sequence of the tagatose 6-phosphate pathway gene cluster of the lactose operon of Lactococcus lactis". J. Biol. Chem. 266 (11): 7176–81. doi:10.1016/S0021-9258(20)89626-4. PMID 1901863.