Sophus or Sofus is a male given name. Notable people with the given name include:

• Sophus Aars (1841–1931), Norwegian civil servant and writer
• Sophus Andersen (1859–1923), Danish composer and music critic
• Sophus Black (1882–1960), Danish telegraph manager and art collector
• Sophus Bugge (1833–1907), Norwegian philologist and linguist
• Sophus Christensen (1848–1920), Norwegian military officer
• Sophus Frederik Kühnel (1851–1930), Danish architect
• Sophus Hagen (1842–1929), Danish composer
• Sophus Halle (1862–1924), Danish composer
• Sophus Hansen (1889–1962), Danish amateur football (soccer) player and referee
• Sophus Lie (1842–1899), Norwegian mathematician
• Sophus Michaëlis (1865–1932), Danish poet, novelist and playwright
• Sophus Müller (1846–1934), Danish archaeologist
• Sophus Nielsen (1888–1963), Danish amateur football player and manager
• Sophus Ruge (1831–1903), German geographer and historian
• Sophus Schandorph (1836–1901), Danish poet and novelist
• Sophus August Wilhelm Stein (1797–1868), Danish surgeon and anatomist
• Sophus Thalbitzer (1871–1941), Danish psychiatrist
• Sophus Torup (1861–1937), Danish physiologist
• Sophus Wangøe (1873–1943), Danish cinematographer
• Sophus Weidemann (1836–1894), Norwegian engineer and industrialist
• Sophus Keith Winther (1893–1983), Danish-American professor and novelist

• Carl Sofus Lumholtz (1851–1922), Norwegian explorer and ethnographer
• Sofus Arctander (1845–1924), Norwegian politician
• Sofus Berger (born 2003), Danish footballer
• Sofus Heggemsnes (born 1999), Norwegian artistic gymnast
• Sofus Johansen (1900–1974), Danish football player and manager
• Sofus Madsen (1881–1977), Norwegian sculptor
• Sofus Rose (1894–1974), Danish long-distance runner

• Father of Four and Uncle Sofus, 1957 Danish film