Smythe, a less common spelling of the surname Smith, may refer to:

• Conn Smythe (1895–1980), Canadian businessman, soldier and sportsman in ice hockey and horse racing
• Dallas Smythe (1907–1992), Canadian political activist and researcher
• Danny Smythe (1948–2016), American drummer, member of the rock band The Box Tops
• Douglas Smythe, American visual effects artist, see Academy Award for Best Visual Effects
• Durham Smythe (born 1995), American football player
• Faye Smythe (born 1985), New Zealand actress
• Frank Smythe (1900–1949), British mountaineer, author, photographer, and botanist
• George Smythe, 7th Viscount Strangford (1818–1857), British politician
• James Moore Smythe (1702–1734), English playwright and fop
• John Smythe (disambiguation) several persons of this name
• Liz Smythe, New Zealand nursing and midwifery professor
• Pat Smythe (pianist) (1923–1983), Scottish jazz pianist
• Pat Smythe (1928–1996), British show jumper
• Percy Smythe, 6th Viscount Strangford (1780–1855), British diplomat
• Percy Smythe, 8th Viscount Strangford (1826–1869), British man of letters
• Peter Smythe (disambiguation) several persons of this name
• Philip Smythe, 2nd Viscount Strangford (1634–1708), English politician
• Quentin Smythe (1916–1997), South African World War II recipient of the Victoria Cross
• Reg Smythe (1917–1998), British cartoonist
• Stafford Smythe (1921–1971), Canadian ice hockey player and manager
• Thomas Smythe (c.1558–1625), English merchant and politician
• Thomas Smythe, 1st Viscount Strangford (1599–1635)
• William Smythe (disambiguation) several persons of this name

• Alan Smythe, character in British TV series Monarch of the Glen
• Alistair Smythe, Spider-Man villain
• Coran Heironymus Wimbledon Smythe, Voltron: Legendary Defender character
• Evelyn Smythe, Doctor Who character
• Greenlee Smythe in American TV soap opera All My Children
  • Mary Greenlee Smythe, her mother
• Ira Smythe, mercenary in video game Jagged Alliance 2
• Jane Smythe, X-Men villain
• President-for-Life Smythe of Null Island
• Reginald Ponsonby-Smythe in video game Destroy All Humans! 2
• Samantha Smythe in American comic book series That Wilkin Boy
• Samson Smythe in That Wilkin Boy
• Sheila Smythe in That Wilkin Boy
• Sebastian Smythe in American musical comedy-drama TV series Glee
• Smythe (Ninjago), a character in Ninjago
• Spencer Smythe, Spider-Man villain
• Sylvester P. Smythe, mascot of American humor magazine Cracked
• Fallon Smythe, Actress and Singer in TV show Gotham Knights