Singleton is a surname. People with the surname include:

• Al Singleton (born 1975), American football linebacker
• Alvin Singleton (born 1940), American composer
• Antron Singleton, known as Big Lurch (born 1976), American rapper and cannibal
• Benjamin "Pap" Singleton (1809–1892), African American separatist leader
• Billy Singleton (born 1968), British basketball player
• C. T. Singleton, Jr., (1905–1977), American admiral
• Charles Laverne Singleton (1959–2004), executed inmate
• Charles Singleton (songwriter) (1913–1985), American songwriter
• Charles S. Singleton (1909–1985), American critic of literature
• Chris Singleton (musician) (born 1977), Irish musician
• Chris Singleton (American football) (born 1967), American football player
• Chris Singleton (baseball) (born 1972), American baseball player
• Eric Singleton Jr., American football player
• Frederick W. Singleton (1858–1941), New York assemblyman
• George Singleton, (born 1958), American writer
• Gordon Singleton (born 1956), Canadian Olympic cyclist
• Harry Singleton (1877–1948), English footballer
• Henry Earl Singleton (1916–1999), co-founder of Teledyne
• IronE Singleton (born 1975), American actor
• James Singleton (basketball) (born 1981), American professional basketball player
• Jim Singleton (born 1931), New Orleans politician
• John Singleton (1968–2019), American film director, producer, and screenwriter
• John Singleton (Australian entrepreneur) (born 1942) Australian entrepreneur
• Jon Singleton (born 1991) American baseball player
• Ken Singleton (born 1947), American baseball player and sportscaster
• Kenneth Singleton (born 1951), American economist
• Lawrence Singleton (1927–2001), American criminal
• Malachi Singleton (born 2004), American football player
• Mark Singleton (actor) (1919–1986), British actor
• Mark Singleton (politician) (1762–1840), Anglo-Irish politician
• Michael Singleton (1913–2002), English cricketer
• Mike Singleton (1951–2012), British programmer
• Penny Singleton (1908–2003), American actress
• Robert Singleton (priest) (died 1544), English Roman Catholic priest
• Robert Singleton (activist) (born 1936), Freedom Rider during 1961
• Robert Corbet Singleton (1810–1881), Irish academic and hymnwriter
• Robert S. Singleton (born 1933), American engineer and inventor
• Roger Singleton-Turner, British television director
• Sandy Singleton (1914–1999), English cricketer
• Theresa A. Singleton (born 1952), American archaeologist and writer
• Thomas Singleton (academic) (1552–1614), Vice-Chancellor of the University of Oxford
• Thomas Singleton (priest) (1783–1842), Archdeacon of Northumberland
• Thomas D. Singleton (died 1833), US Representative from South Carolina
• Tommy Singleton (1940–2005), English footballer
• Valerie Singleton (born 1937), British television and radio presenter
• Walter K. Singleton (1944–1967), Medal of Honor recipient
• William Singleton (politician) (died 1677), English politician in the English Civil War
• William Dean Singleton (born 1951), founder and CEO of MediaNews Group
• Zutty Singleton (1898–1975), American jazz drummer