A significant other is a partner in an intimate relationship.

Significant Other or Significant Others may also refer to:

• Significant Other (film), a 2022 American sci-fi horror film
• Significant Other (TV series), a 2023 British comedy drama series on ITV
• Significant Others (1998 TV series), an American drama series on the Fox Network
• Significant Others (2004 TV series), an American sitcom on Bravo
• Significant Others (2022 TV series), an Australian TV series

• "significANT other", an episode from season 2 of A.N.T. Farm
• "Significant Other", an episode from season 1 of People of Earth
• "Significant Others", an episode from season 5 of Castle
• "Significant Others", an episode from season 1 of Hearts Afire
• "Significant Others", an episode from season 3 of Party of Five
• "Significant Others", an episode from season 1 of QB1: Beyond the Lights
• "Significant Others", an episode from season 3 of Roswell
• "Significant Others", an episode from the web series The Outs
• "Significant Others", an episode from season 2 of The Smoking Room

• Significant Other (album), a 1999 album by Limp Bizkit
• Significant Other (play), a 2015 stage play
• Significant Others (novel), a 1987 work by Armistead Maupin

• All pages with titles beginning with Significant Other
• All pages with titles containing Significant Other or All pages with titles containing Significant Others