Sodium-dependent neutral amino acid transporter B(0)AT2 is a protein that in humans is encoded by the SLC6A15 gene.[5]
Function
SLC6A15 shows structural characteristics of an Na+ and Cl−-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[6]
Clinical relevance
Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000072041 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019894 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: solute carrier family 6 (neutral amino acid transporter)".
- ^ Farmer MK, Robbins MJ, Medhurst AD, Campbell DA, Ellington K, Duckworth M, Brown AM, Middlemiss DN, Price GW, Pangalos MN (Dec 2000). "Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family". Genomics. 70 (2): 241–52. doi:10.1006/geno.2000.6387. PMID 11112352.
- ^ Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB (Apr 2011). "The neuronal transporter gene SLC6A15 confers risk to major depression". Neuron. 70 (2): 252–65. doi:10.1016/j.neuron.2011.04.005. PMC 3112053. PMID 21521612.
Further reading
- Bröer A, Tietze N, Kowalczuk S, Chubb S, Munzinger M, Bak LK, Bröer S (Jan 2006). "The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2)". The Biochemical Journal. 393 (Pt 1): 421–30. doi:10.1042/BJ20051273. PMC 1383701. PMID 16185194.
- Zaia KA, Reimer RJ (Mar 2009). "Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport". The Journal of Biological Chemistry. 284 (13): 8439–48. doi:10.1074/jbc.M806407200. PMC 2659202. PMID 19147495.
- Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Bröer S (Jan 2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiological Reviews. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
- Takanaga H, Mackenzie B, Peng JB, Hediger MA (Nov 2005). "Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain". Biochemical and Biophysical Research Communications. 337 (3): 892–900. doi:10.1016/j.bbrc.2005.09.128. PMID 16226721.
- Masson J, Sagné C, Hamon M, El Mestikawy S (Sep 1999). "Neurotransmitter transporters in the central nervous system". Pharmacological Reviews. 51 (3): 439–64. PMID 10471414.
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