The Tamil and Malayali name Ramachandran may refer to:

• A. Ramachandran (born 1935), an Indian painter
• A. Ramachandran (politician) the incumbent mayor of Salem, Tamil Nadu
• C. R. Ramachandran, an Indian politician
• G. Ramachandran (1904–1995), an Indian social reformer and politician
• Gopalasamudram Narayana Iyer Ramachandran (1922–2001), an Indian biophysicist known for creating the Ramachandran plot
• K. V. Ramachandran (1898–1956), an Indian music and art critic
• M. Ramachandran, an Indian politician
• M. D. R. Ramachandran (1934–2024), an Indian politician
• M. G. Ramachandran, also known as MGR (1917–1987), an Indian film actor and former Chief Minister of Tamil Nadu
• N. S. Ramachandran (born 1908 (?)), an Indian composer of Carnatic music
• P. P. Ramachandran, an Indian poet
• R. Ramachandran, an Indian poet
• Subramaniam Ramachandran, a missing Sri Lankan journalist
• T. Ramachandran (CPI politician), an Indian politician
• T. Ramachandran (INC politician), an Indian politician
• T. Ramachandran (writer) (1944–2000), an Indian author
• T. A. Ramachandran (1912–1951), an Indian cricket umpire
• T. K. Ramachandran (died 1993), an Indian film actor and producer
• T. N. Ramachandran (1903–1973), an Indian art historian, artist, archaeologist, and Sanskrit scholar
• T. R. Ramachandran (1917–1990), an Indian actor and comedian
• Thechikottukavu Ramachandran (born c.  1964), a controversial elephant
• V. S. Ramachandran (born 1951), an Indian-American neuroscientist
• Asogan Ramesh Ramachandren (c. 1973–1998), a Singaporean convicted murderer

• Ramachandran Ramesh (born 1976), an Indian chess grandmaster
• N. Ramachandran Gingee (born 1944), an Indian politician
• S. Ramachandran Pillai (born 1938), an Indian politician

• Ramachandran plot, a biochemical method
• Ramachandra, a deity of Hinduism