The Quad Cities is a region of cities on the border of the U.S. states of Iowa and Illinois.

Quad Cities may also refer to:

• Florence-Muscle Shoals Metropolitan Area, in Alabama, United States
• Quad Cities Metropolitan Area, the metropolitan area associated with the Quad Cities in Iowa and Illinois
• Quad Cities (Minnesota), the cities of Virginia, Eveleth, Gilbert, and Mountain Iron in Minnesota, United States
• Quad Cities (Arizona), Prescott, Arizona in the United States, and nearby cities

• Quad Cities (train), a planned Amtrak train to the Iowa-Illinois Quad Cities
• Quad Cities Rocket, a defunct Chicago, Rock Island and Pacific Railroad train to the Iowa-Illinois Quad Cities
• Quad City DJ's, an American hip-hop music group
• Quad Cities Nuclear Generating Station, an Illinois nuclear power plant.

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