Off or OFF may refer to:

• Off (video game), a video game by Mortis Ghost.
• Sven Väth, German DJ and singer who uses the pseudonym OFF
• Off (album), by Ciwan Haco, 2006
• Off! (album), by Off!
• Off!, an American hardcore punk band
• "Off", a song by Royce da 5'9" from Layers
• "Off", a song by the American band Bright from their self-titled album
• Our Favorite Family, a nickname for the Simpson family in the animated television series The Simpsons

• OFF (file format), for polygon meshes
• Open Font Format
• Owner-Free File System, a P2P network

• Offutt Air Force Base, near Omaha, Nebraska
• Oil-for-Food Programme, the United Nations arrangement with Iraq in existence from 1995 to 2003
• United States Office of Facts and Figures (OFF); see OWI (United States Office of War Information)

• Of, a city in Turkey
• Off, spoiled, as in drinks and foods that have exceeded their shelf life
• Off side, one half of a cricket field
• Off! (brand), an insect repellent
• Open Food Facts, a crowdsourced database
• Over Flanders Fields, a 2005 combat flight simulation video game set in World War I;
• Carol Off, Canadian journalist
• Oslo Freedom Forum, series of global conferences run by Human Rights Foundation

• Offside (disambiguation)
• ORF (disambiguation)
• Orff (disambiguation)