Michael Simpson or Mike Simpson may refer to:

• Michael Simpson (painter) (born 1940), English painter
• Michael Simpson (producer), American record producer and member of the electronic group Dust Brothers
• Mike Simpson (Caulfields), guitarist of the rock group The Caulfields
• Mickey Simpson (1913–1985), American actor
• M. J. Simpson, British movie journalist, author and screenwriter
• Michael A. Simpson, director of sequels to the cult horror film Sleepaway Camp

• Mike Simpson (Michigan politician) (1962–2009), member of the Michigan House of Representatives
• Mike Simpson (born 1950), U.S. congressman from Idaho

• Mike Simpson (American football) (born 1947), American football player
• Michael Simpson (footballer) (born 1974), British footballer

• Michael Simpson Culbertson (1819–1862), American clergyman and missionary