Luque may refer to:

• Luque, a city in Central Department, Paraguay
• Luque, Spain, a city in Spanish province of Córdoba

Luque is a surname of Spanish and Portuguese origin. Notable people with the name include:

• Agustin de Luque y Coca (1850–1937), Spanish military general and Minister of War
• Alan Luque (b. 1999), Argentine footballer
• Albert Luque (b. 1979), Spanish footballer
• Antonio Luque (b. 1941), Spanish scientist and entrepreneur in the field of photovoltaic solar energy
• Aurora Luque (b. 1962), Spanish writer, poet, translator and teacher
• Carlos Luque (b. 1993), Argentine footballer
• Crisanto Luque Sánchez (1889–1959), Colombian cardinal of the Roman Catholic Church
• Dolf Luque (1890–1957), Cuban Major League Baseball pitcher
• Eduardo Castro Luque, assassinated Mexican politician
• Francisco Luque (b. 1948), Spanish sculptor
• Gregorio Luque (1942–2026), Mexican baseball player and manager
• Hernando de Luque (d. 1533), Spanish priest
• Joan Luque (b. 1992), Spanish footballer
• Joaquín Luque Roselló (1865–1932), Spanish painter
• Jorge Luque (b. 1981), Spanish footballer
• Jorge Luque (cyclist) (1936–2024), Colombian cyclist
• José Antonio Luque (b. 1974), Spanish footballer who played as goalkeeper
• José Juan Luque (b. 1977), Spanish footballer
• Julián Luque (b. 1992), Spanish footballer
• Leopoldo Luque (1949–2021), Argentine football player
• Luis Luque (b. 1956), Argentine film and television actor
• Manuel Luque (1853/54–1924), Spanish-born caricaturist, lithographer, designer and painter, who spent most of his career in Paris
• Marco Luque (b. 1974), Brazilian comedian
• Maria Josep Colomer i Luque (1913–2004), pioneering female pilot from Barcelona
• Mauro Luque (b. 1999), Argentine footballer
• Miguel Ángel Luque (b. 1990), Spanish footballer
• Miguel Luque Ávila (b. 1976), Spanish Paralympic swimmer
• Samuel de Luque Batuecas (b. 1989), known online as Vegetta777, Spanish gaming YouTuber
• Santi Luque (b. 1993), Spanish footballer
• Sergio Luque, Mexican composer
• Vicente Luque (b. 1991), Brazilian mixed martial artist
• Virginia Luque (1927–2014), Argentine tango singer and film actress