The following highways are numbered 351:

• Manitoba Provincial Road 351
• Newfoundland and Labrador Route 351
• Prince Edward Island Route 351
• Quebec Route 351

• Calzada de Jústiz (2–351)

• Japan National Route 351

• National Highway 351

• Arkansas Highway 351
• County Road 351 (Dixie County, Florida)
  • County Road 351A (Dixie County, Florida)
• Georgia State Route 351 (former)
• Illinois Route 351
• Kentucky Route 351
• Louisiana Highway 351
• Maryland Route 351
• New York:
  • New York State Route 351
    • New York State Route 351 (former)
  • County Route 351 (Albany County, New York)
• Oklahoma State Highway 351 also known as Muskogee Turnpike
• Oregon Route 351
• Pennsylvania Route 351
• Puerto Rico Highway 351
• Tennessee State Route 351
• Texas State Highway 351
• Virginia State Route 351
  • Virginia State Route 351 (former)
• Wisconsin Highway 351 (former)
• Wyoming Highway 351