The following highways are numbered 341:

• Manitoba Provincial Road 341
• Newfoundland and Labrador Route 341
• Nova Scotia Route 341
• Prince Edward Island Route 341
• Quebec Route 341

• National Highway 341

• Japan National Route 341

• U.S. Route 341
• Arkansas Highway 341
• Connecticut Route 341
• Georgia State Route 341
• Indiana State Road 341
• Louisiana Highway 341
• Maryland Route 341
• Nevada State Route 341
• New York:
  • New York State Route 341 (former)
    • New York State Route 341 (former)
  • County Route 341 (Erie County, New York)
• Pennsylvania Route 341
• Puerto Rico Highway 341
• Tennessee State Route 341
• Texas State Highway 341
• Virginia State Route 341
• Wisconsin Highway 341
• Wyoming Highway 341