Route 260, or Highway 260, may refer to:

• Loddon Valley Highway

• Manitoba Provincial Road 260
• New Brunswick Route 260
• Prince Edward Island Route 260

• Japan National Route 260

• State road D.260 (Turkey)

• U.S. Route 260 (former)
• Arizona State Route 260
• California State Route 260
• Georgia State Route 260
• K-260 (Kansas Highway)
• Kentucky Route 260
• Maryland Route 260
• New York State Route 260
• Ohio State Route 260
• Oregon Route 260
• Pennsylvania Route 260 (former)
• South Carolina Highway 260
• Tennessee State Route 260
• Texas State Highway 260 (former)
  • Texas State Highway Loop 260 (former)
  • Texas State Highway Spur 260
• Utah State Route 260
• Washington State Route 260