The following highways are numbered 222:

• Manitoba Provincial Road 222
• Newfoundland and Labrador Route 222
• Prince Edward Island Route 222
• Quebec Route 222

• China National Highway 222

• National Route 222

• Main road 222 (Hungary)

• National Highway 222 (India)

• Japan National Route 222

• Thailand Route 222

• A222 road
• B222 road

• Interstate 222 (future)
• U.S. Route 222
• Arkansas Highway 222
• California State Route 222
• Connecticut Route 222
• Florida State Road 222
• Georgia State Route 222 (former)
• K-222 (Kansas highway) (former)
• Kentucky Route 222
• Maine State Route 222
• Maryland Route 222
• M-222 (Michigan highway)
• Minnesota State Highway 222
• Montana Secondary Highway 222
• New York State Route 222
• North Carolina Highway 222
• Ohio State Route 222
• Oregon Route 222
• Pennsylvania Route 222
• Tennessee State Route 222
• Texas State Highway 222
• Utah State Route 222
• Virginia State Route 222
• Wyoming Highway 222