Route 199, or Highway 199, may refer to:

• Quebec Route 199

• Route 199-CH in Araucanía Region

• Japan National Route 199

• B199 road
• A199 road

• U.S. Route 199
• Alabama State Route 199
• California State Route 199
• Connecticut Route 199
• Georgia State Route 199
• Illinois Route 199 (former)
• Iowa Highway 199 (former)
• K-199 (Kansas highway)
• Kentucky Route 199
• Maine State Route 199
• M-199 (Michigan highway)
• New York State Route 199
• Ohio State Route 199
• Oklahoma State Highway 199
• Pennsylvania Route 199
• Tennessee State Route 199
• Texas State Highway 199
  • Texas State Highway Spur 199
  • Farm to Market Road 199
• Utah State Route 199
• Virginia State Route 199
• Wisconsin Highway 199 (former)

Territories:

• Puerto Rico Highway 199