Laker or Lakers may refer to:

• Los Angeles Lakers, an NBA basketball team from Los Angeles, California, United States

• Clayton State Lakers, the NCAA Division II athletic program of Clayton State University in Morrow, Georgia
• Grand Valley State Lakers, the athletic program of Grand Valley State University, an NCAA Division II school in Allendale, Michigan
• Iowa Lakes Community College Lakers, located in Estherville, Iowa
• Lake Superior State Lakers, the athletic program of Lake Superior State University, an NCAA Division II school in Sault Ste. Marie, Michigan that fields an NCAA Division I men's ice hockey team
• Mercyhurst Lakers, the athletic program of Mercyhurst University, an NCAA Division I school in Erie, Pennsylvania
• Nipissing Lakers, competing in Ontario University Athletics, in North Bay, Ontario
• Roosevelt Lakers, the athletic program of Roosevelt University, an NCAA Division II school in Chicago, Illinois
• State University of New York at Oswego (Oswego State) Lakers, an NCAA Division III school, in Oswego, New York

• Bonneville High School (Washington Terrace, Utah) Lakers
• Calloway County High School Lakers, Murray, Kentucky
• Danbury High School Lakers, Marblehead, Ohio
• Detroit Lakes High School Lakers, Detroit Lakes, Minnesota
• Indian Lake High School Lakers, Lewistown, Ohio
• Mercyhurst Preparatory School Lakers, Erie, Pennsylvania
• Cazenovia High School Lakers, Cazenovia, New York
• Skaneateles High School Lakers, Skaneateles, New York
• West Bloomfield High School Lakers, West Bloomfield, Michigan
• Penticton Secondary School Lakers, Penticton, British Columbia

• Doncaster Lakers, a British rugby league club
• Hutt Valley Lakers, a former basketball team based in Wellington, New Zealand
• Laguna Lakers, a defunct basketball team based in Laguna, Philippines
• Penticton Lakers, a Canadian ice hockey team
• Peterborough Lakers Jr. A, a box lacrosse team from Peterborough, Ontario, Canada
• Rapperswil-Jona Lakers, a Swiss ice hockey team
• South Bay Lakers, a team in the NBA G League
• Växjö Lakers, a Swedish ice hockey team in Swedish Hockey League

• Laker (surname)
• Lake freighter or laker, a type of cargo ship
• Laker Airways, an airline company
• Laker Beer, a brand of beer sold in Canada