James Mackey is a professional poker player.

James Mackey or Jim Mackey may also refer to:

• James Mackey (mayor) (1813–1892), Lord Mayor of Dublin
• James Mackey (theologian), Catholic theologian
• James Page Mackey (1913–2009), chief of police
• Biz Mackey (James Raleigh Mackey), American catcher and manager in Negro league baseball
• Jim Mackey (footballer) (1897–1990), English footballer
• Jim Mackey (administrator), British NHS executive

• James Mackie (disambiguation)
• James Mackay (disambiguation)
• James McKay (disambiguation)