Guglielmo Sanfelice d'Acquavilla O.S.B.Cas. (14 April 1834 – 3 January 1897) was a Cardinal of the Roman Catholic Church and Archbishop of Naples.

Sanfelice d'Acquavilla was born in Aversa, Italy, on 14 April 1834.^{[citation needed]}

He was appointed Archbishop of Naples in 1878 and served until his death in 1897.^[1]

He was made cardinal by Pope Leo XIII in 1884.^{[citation needed]}

Sanfelice d'Acquavilla died in Naples on 3 January 1897.^{[citation needed]}