Exonuclease 5 is a protein that in humans is encoded by the EXO5 gene. [5]

Function

The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164002 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028629 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Exonuclease 5". Retrieved 2018-04-27.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Allikas: https://en.wikipedia.org/wiki/Exonuclease_5
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