David Burke may refer to:

• David Burke (British actor) (born 1934), British television actor
• David J. Burke (born 1948), American producer, screenwriter and film and television director
• David Burke (American actor) (born 1967), American television actor
• David Burke (author), writer on slang and idioms
• David Burke, author of a book on Melita Norwood
• D4vd (David Anthony Burke, born 2005), American singer and songwriter

• Dave Burke (Australian footballer) (1916–1987), Australian rules footballer
• David Burke (Australian footballer, born 1959), Australian rules footballer
• David Burke (English footballer) (born 1960), English footballer
• David Burke, competitor in the 1986 IAAF World Cross Country Championships – Junior men's race
• David Burke (boxer) (born 1975), English boxer
• David Burke (Kilkenny hurler) (born 1981), Irish hurler for Kilkenny and Wexford
• Davy Burke (born 1988), Irish Gaelic football manager and former player
• David Burke (Galway hurler) (born 1990), Irish hurler for Galway
• David Burke, soccer player for Albany BWP Highlanders

• David Burke (botanist) (1854–1897), English botanist
• David W. Burke (1935–2014), American television news executive
• David Burke (neurophysiologist) (born 1944), Australian expert in spinal and brain trauma
• David A. Burke (1952–1987), American hijacker and former employee who caused the crash of Pacific Southwest Airlines Flight 1771
• David Burke (chef) (born 1962), chef and restaurateur
• David Burke (politician) (born 1967), member of the Ohio House of Representatives
• David "Bombhead" Burke, a character played by Lee Otway on the British TV soap opera Hollyoaks

• David Noel Bourke (born 1970), Irish filmmaker
• David Bourke (born 1976), Australian rules footballer
• David de Búrca, 16th century Irish chieftain