The Atacama Desert is the most arid desert in the world which is located in Chile.

Atacama may refer to:

• Atacama people (Likan Antaí), indigenous people of Chile

• Atacama Region, first-order administrative division of Chile
• Atacama Province, Bolivia, former province of Bolivia
• Atacama Province, Chile, former province of Chile
• Atacama Department, former department of Bolivia, now in Chile

• Atacama Trench, oceanic trench running along the west coast of South-America
• Puna de Atacama, high plateau in the Andes
• Atacama Fault
• Atacama Lacuna, intermittent lake on the Saturn moon Titan

• Atacama border dispute, territorial dispute between Chile and Bolivia
• Puna de Atacama dispute, territorial dispute between Chile and Argentina
• 18725 Atacama, a minor planet