5-Allyloxy-AMT, also known as 5-allyloxy-α-methyltryptamine, is a serotonin 5-HT2 receptor agonist of the tryptamine, 5-alkyloxytryptamine, and α-alkyltryptamine families.[1]

It is known to act as high-efficacy partial agonist or near-full agonist of the serotonin 5-HT2A receptor (EC50Tooltip half-maximal effective concentration = 162 nM; EmaxTooltip maximal efficacy = 89%) and of the serotonin 5-HT2B receptor (EC50 = 60 nM; Emax = 82%), whereas activity at the serotonin 5-HT2C receptor and other serotonin receptors was not reported.[1]

5-Allyloxy-AMT was the most potent serotonin 5-HT2A receptor agonist reported in a large series of tryptamines that was evaluated in search of potent and selective serotonin 5-HT2B receptor agonists.[1] The only exceptions were the reference serotonin 5-HT2A receptor agonists serotonin (5-HO-T) (EC50 = 79 nM; Emax = 100%) and (S)-α-methylserotonin ((S)-αMS) (EC50 = 54 nM; Emax = 103%).[1]

See also

References

  1. ^ a b c d Schumacher M (2008). Chirale Arylmethoxytryptamine als 5-HT2B-Rezeptoragonisten: Synthese, Analytik und in-vitro-Pharmakologie [Chiral arylmethoxytryptamines as 5-HT2B receptor agonists: synthesis, analysis, and in vitro pharmacology] (Thesis). doi:10.5283/EPUB.10667.


Allikas: https://en.wikipedia.org/wiki/5-Allyloxy-AMT
No tags for this post.