The 2022 Challenger Coquimbo II was a professional tennis tournament played on clay courts. It was part of the 2022 ATP Challenger Tour. It took place in Coquimbo, Chile between 17 and 23 October 2022.

Country	Player	Rank1	Seed
ARG	Federico Coria	72	1
ARG	Tomás Martín Etcheverry	89	2
GER	Daniel Altmaier	102	3
ITA	Marco Cecchinato	117	4
ARG	Camilo Ugo Carabelli	123	5
KAZ	Timofey Skatov	152	6
ARG	Juan Manuel Cerúndolo	155	7
ITA	Franco Agamenone	158	8

• Rankings are as of 10 October 2022.^[1]

The following players received wildcards into the singles main draw:

• Diego Fernández Flores
• Matías Soto
• Daniel Vallejo

The following players received entry into the singles main draw as alternates:

• Román Andrés Burruchaga
• Juan Pablo Paz
• Thiago Seyboth Wild

The following players received entry from the qualifying draw:

• Rémy Bertola
• Sumit Nagal
• Jakub Paul
• Daniel Rincón
• Fermín Tenti
• José Francisco Vidal Azorín

• Juan Manuel Cerúndolo def. Facundo Díaz Acosta 6–3, 3–6, 6–4.

• Franco Agamenone / Hernán Casanova def. Karol Drzewiecki / Jakub Paul 6–3, 6–4.