The 2018 Città di Caltanissetta was a professional tennis tournament played on clay courts. It was the 20th edition of the tournament which was a part of the 2018 ATP Challenger Tour. It took place in Caltanissetta, Italy between 11 and 17 June 2018.

Country	Player	Rank1	Seed
ITA	Paolo Lorenzi	74	1
URU	Pablo Cuevas	75	2
CZE	Jiří Veselý	80	3
JPN	Taro Daniel	82	4
SRB	Laslo Đere	101	5
ARG	Guido Andreozzi	108	6
BRA	Thiago Monteiro	123	7
ITA	Stefano Travaglia	143	8

• ¹ Rankings are as of 28 May 2018.

The following players received wildcards into the singles main draw:

• Filippo Baldi
• Alejandro Davidovich Fokina
• Omar Giacalone
• Gian Marco Moroni

The following players received entry from the qualifying draw:

• Marco Bortolotti
• Federico Gaio
• Marc Sieber
• Miljan Zekić

The following players received entry as lucky losers:

• Martín Cuevas
• Maxime Janvier

• Jaume Munar def. Matteo Donati 6–2, 7–6^(7–2).

• Federico Gaio / Andrea Pellegrino def. Blaž Rola / Jiří Veselý 7–6^(7–4), 7–6^(7–5).

• Official Website