20α-Dihydrotrengestone (20α-DHTG), also known as 20α-hydroxytrengestone, as well as 6-chloro-20(S)-hydroxy-9β,10α-pregna-1,4,6-trien-3-one, is a progestin and the major active metabolite of trengestone.[1][2] It appears that trengestone is a prodrug of 20α-DHTG, as it is largely transformed into this metabolite when given orally in humans.[2][1] 20α-DHTG has potent progestogenic activity similarly to trengestone.[1]

See also

References

  1. ^ a b c d Dixon R, Tormey P, Darragh A (March 1975). "Disposition of the retro-steroid progestogen, 6-chloro-9beta, 10alpha-pregna-1,4,6-triene-3,20-dione (Ro 4-8347), in man". Contraception. 11 (3): 339–46. doi:10.1016/0010-7824(75)90042-6. PMID 1116370.
  2. ^ a b Breuer H, Kime DE, Knuppen R (September 1973). "Metabolism of 6-chloro-9 beta, 10 alpha-pregna-1,4,6-triene-3,20-dione in rat, rabbit, monkey and man". Acta Endocrinol. 74 (1): 127–43. doi:10.1530/acta.0.0740127. PMID 4202495.


Allikas: https://en.wikipedia.org/wiki/20%CE%B1-Dihydrotrengestone
No tags for this post.