Events from the year 1600 in Ireland.

• Monarch: Elizabeth I

• January – Nine Years' War against England is renewed by Hugh O'Neill, 2nd Earl of Tyrone, with an invasion of Munster.^[1]
• 27 January – Colonel Richard Wingfield is made Marshal of Ireland by Queen Elizabeth.
• 18 February – Nine Years' War: Rebel cavalry in Munster led by Hugh Maguire (Lord of Fermanagh) are intercepted and their leaders killed.
• 15 May – Nine Years' War: Chief Niall Garbh Ó Domhnaill betrays the Irish alliance and allows Henry Docwra to land at Lough Foyle with an expeditionary force of 4,000 men. In a devastating blow to the rebels, Docwra sets up a series of fortifications along the River Foyle, cutting access between Tír Eoghain and Tyrconnell.
• 20 September – 9 October: the Battle of Moyry Pass is fought. Lord Mountjoy's English forces eventually break through Hugh O'Neill's defences in County Armagh and establish a short-lived garrison at Mountnorris but later retreat.

• Aedh O'Rourke, son of Tadhg O'Rourke of West Breifne and Mary O'Donnell of Tyrconnell.
• Heber MacMahon, Roman Catholic Bishop of Clogher (d. 1650)
• Terence Albert O'Brien, Roman Catholic Bishop of Emly, (d. 1651)
• John Temple, judge and politician (d. 1677)
• Approximate date
  • John Colgan, hagiographer and historian (d. c.1657)
  • James Dillon, Confederate officer (d. after 1669)
  • Piaras Feiritéar, poet and harpist (d. 1653)
  • Rory O'Moore, landowner, noble and rebel leader (d. 1655)

• 18 February – Hugh Maguire, Lord of Fermanagh and prominent rebel leader, is killed in Munster.
• Baothghalach Mór Mac Aodhagáin, poet (b. 1550)