Columella, meaning little column, may refer to:

• Lucius Columella, a 1st-century CE Roman writer on agriculture

• Columella (auditory system), a part of the auditory system of amphibians, reptiles and birds
• Columella (botany), an axis of sterile tissue which passes through the center of the spore-case of mosses and a cellular layer near the tip of a plant's root cap
• Columella (gastropod), an anatomical feature of a coiled snail or gastropod shell
• Columella (genus), a genus of land gastropods in the family Vertiginidae
• Columella (plant), a cultivar of Dutch elm
• Columella nasi, the fleshy external end of the nasal septum
• In corals, the central axis structure of a corallite formed by the inner ends of the septa

• Columella (wine), a wine label by South African producer The Sadie Family
• Columella; or, The Distressed Anchoret, a 1779 novel by Richard Graves

• Collum (disambiguation)
• Column (disambiguation)