Isabelle is a feminine given name. Notable people with the name include:

• Isabelle of Luxembourg (1247–1298), a daughter of Henry V of Luxembourg and his wife Margaret of Bar
• Isabelle of Orléans (disambiguation)
• Princess Isabelle (disambiguation)
• Isabelle Abiera (born 1992), a Filipina actress and model
• Isabelle Adjani (born 1955), a French film actress and singer
• Isabelle Antena, a French singer
• Isabelle Arnould (born 1970), a Belgian female freestyle swimmer
• Isabelle Aubret (born 1938), a French singer
• Isabelle Autissier (born 1956), a French sailor, navigator, writer and broadcaster
• Isabelle Amyes (born 1950), an English actress
• Isabelle Bean (1862 – 1939), an Australian nurse, theosophist and feminist
• Isabelle Blais, a Canadian actress and musician
• Isabelle Blanc (born 1975), a French snowboarder and Olympic champion
• Isabelle Boulay (born 1972), a francophone Canadian pop singer
• Isabelle Boulogne (born 1971), a French sprint canoer
• Isabelle Brasseur (born 1970), a Canadian figure skater
• Isabelle Breitman (born 1959), a French actress and director
• Isabelle von Bueltzingsloewen (born 1964), a French academic and historian
• Isabelle Buret, a French telecommunications and space science engineer
• Isabelle Le Callennec (born 1966), French politician
• Isabelle Rauch (born 1968), French politician
• Isabelle Carbonell, a Belgio-Uruguayan documentary photographer and filmmaker
• Isabelle Caro, a French model suffering from severe anorexia nervosa
• Isabelle Carré (born 1971), a French actress
• Isabelle Champmoreau (born 1974), a New Caledonian politician
• Isabelle Charest (born 1971), a Canadian short track speed skater
• Isabelle Chartrand (born 1978), a Canadian ice hockey player
• Isabelle Cheng (born 1970), an intelligence agent
• Isabelle Collin Dufresne (aka Ultra Violet, 1935–2014), a French-American artist
• Isabelle Corey (1939–2011), a French film actress
• Isabelle Coutant-Peyre (born 1952), a French lawyer
• Isabelle Daniels (1937–2017), an American athlete, who mainly competed in the 100 metres
• Isabelle de Charrière (1740–1805), a Dutch-born writer of the Enlightenment
• Isabelle de Craon (c.1212–??), a French noblewoman
• Isabelle Debré (born 1957), a member of the Senate of France
• Isabelle Delobel (born 1978), a French figure skater
• Isabelle Delorme (1900–1991), a Canadian composer, pianist and music educator
• Isabelle de Meulan (c. 1148 – 1220), a French noblewoman
• Isabelle Demongeot (born 1966), a former French professional tennis player
• Isabelle de Montolieu (1751–1832), a Swiss novelist and translator
• Isabelle Despres, a French slalom canoer
• Isabelle Devaluez (born 1966), a French discus thrower
• Isabelle Diks (born 1965), a Dutch GreenLeft politician
• Isabelle Dinoire (born 1967), the first person to undergo a partial face transplant
• Isabelle Duchesnay (born 1963), an ice dancer who competed for both Canada and France
• Isabelle Durant (born 1954), a Belgian politician, member of the Ecolo party
• Isabelle Eberhardt (1877–1904), a Swiss-Algerian explorer and writer
• Isabelle Ferron (born 1967), an actress in both film and stage
• Isabelle Fijalkowski (born 1972), a French basketball player
• Isabelle Flory, a French violinist
• Isabelle Jane Foulkes (1970–2001), Anglo-Welsh artist, textile designer and disability campaigner
• Isabelle Fuhrman (born 1997), an American teen actress
• Isabelle Gatti de Gamond (1839–1905), an Italo-Belgian educationalist, feminist and politician
• Isabelle Gaudeuille (born 1954), Central African Republic lawyer and politician
• Isabelle Goldenson (1920–2005), American lobbyist and philanthropist
• Isabelle Guyon (born 1961), French-born researcher in machine learning
• Isabelle Haak (born 1999), Swedish volleyball player
• Isabelle Bowen Henderson (1899–1969), American painter and floriculturist
• Isabelle Holland (1920–2002), an author of children and adult fiction books
• Isabelle Huppert (born 1953), a French actress
• Isabelle Keith (1898–1979), an American actress
• Isabelle Kridluar (1954–2018), Inuk artist who lived by Repulse Bay, Nunavut, Canada
• Isabelle LaMal (1886–1952), an American film actress
• Isabelle Laville (died 1987), French murder victim
• Isabelle Lendl (born 1991), an American amateur golfer
• Isabelle Li, Singaporean table tennis player
• Isabelle Liberman (1918–1990), an American psychologist
• Isabelle Lucas (1927–1997), a Canadian-born British actress and singer
• Isabelle Mancini (born 1967), a French cross country skier
• Isabelle Mercier (born 1975), a Canadian professional poker player
• Isabelle E. Merry (1907–2000), Australian Congregational minister and chaplain
• Isabelle Mir (born 1949), a French former Alpine skier
• Isabelle Morneau (born 1976), a defender on the Canada women's national soccer team
• Isabelle Mouthon-Michellys (born 1966), a French athlete
• Isabelle Nanty (born 1962), a French actress and film director
• Isabelle Nylander (born 1990), a Swedish figure skater
• Isabelle Olivieri (1957–2016), French biologist, specialising in evolutionary sciences, genetics and population biology
• Isabelle Pasco (born 1966), a French actress and model
• Isabelle Pasquet (born 1962), member of the Senate of France
• Isabelle Pearson (born 1981), Canadian judoka
• Isabelle Peretz, a Professor of Psychology at the University of Montreal
• Isabelle Périgault (born 1971), French politician
• Isabelle Pieman (born 1983), Belgian figure skater
• Isabelle Pinson (1769–1855), French genre painter and portraitist
• Isabelle Rampling (born 1985), Canadian synchronized swimmer
• Isabelle Rezazadeh, also known as Rezz, a Canadian DJ and record producer
• Isabelle Romée (1377–1458), the mother of Joan of Arc
• Isabelle Sadoyan (1928–2017), French actress
• Isabelle Sandy (1884–1975), French poet and writer
• Isabelle Schad (born 1970), German dancer and choreographer
• Isabelle Severino (born 1980), French gymnast and actress
• Isabelle Simonis (born 1967), Belgian politician from the Socialist Party
• Isabelle Stengers (born 1949), Belgian philosopher and the daughter of the historian Jean Stengers
• Isabelle Stoehr (born 1979), French professional squash player
• Isabelle Stone (1868–1944), American physicist
• Isabelle Story (1887–1970), American writer and editor
• Isabelle Thompson (1891–1946), Hawaiian-American teacher and politician
• Isabelle Turcotte Baird (born 1970), Canadian athlete
• Isabelle Urquhart (1865–1907), American stage actress
• Isabelle Vasseur (born 1959), member of the National Assembly of France
• Isabelle Valentin (born 1962), French politician
• Isabelle Vandre (born 1989), German politician
• Isabelle Vengerova (1877–1956), a Russian-born American pianist and music teacher
• Isabelle Wendling (born 1971), a French handball player
• Isabelle Wéry, a Belgian actress and writer
• Isabelle Westbury (born 1990), an English cricketer
• Isabelle White (1894–1972), a British diver
• Isabelle Yacoubou (born 1986), French, of Bénin origin, professional basketball player