4-hydroxybenzaldehyde dehydrogenase
| 4-hydroxybenzaldehyde dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.2.1.64 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, 4-hydroxybenzaldehyde dehydrogenase (EC 1.2.1.64) is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are 4-hydroxybenzaldehyde, oxidised nicotinamide adenine dinucleotide (NAD+), and water. Its products are 4-hydroxybenzoic acid, reduced NADH, and a proton.[1]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-hydroxybenzaldehyde:NAD+ oxidoreductase. This enzyme is also called p-hydroxybenzaldehyde dehydrogenase. This enzyme participates in toluene and xylene degradation in bacteria.[2][3] It is also found in carrots (Daucus carota).[4]
References
- ^ Enzyme 1.2.1.64 at KEGG Pathway Database.
- ^ Bossert ID, Whited G, Gibson DT, Young LY (1989). "Anaerobic oxidation of p-cresol mediated by a partially purified methylhydroxylase from a denitrifying bacterium". J. Bacteriol. 171 (6): 2956–62. doi:10.1128/jb.171.6.2956-2962.1989. PMC 210000. PMID 2722739.
- ^ Whited GM, Gibson DT (1991). "Separation and partial characterization of the enzymes of the toluene-4-monooxygenase catabolic pathway in Pseudomonas mendocina KR1". J. Bacteriol. 173 (9): 3017–20. doi:10.1128/jb.173.9.3017-3020.1991. PMC 207886. PMID 2019564.
- ^ Sircar, D.; Mitra, A. (2008). "Evidence for p-hydroxybenzoate formation involving enzymatic phenylpropanoid side-chain cleavage in hairy roots of Daucus carota". Journal of Plant Physiology. 165 (4): 407–414. Bibcode:2008JPPhy.165..407S. doi:10.1016/j.jplph.2007.05.005. PMID 17658659.
