James Hyde may refer to:

• James Hyde (actor) (born 1962), American actor
• James Hyde (artist) (born 1958), American painter, sculptor and photographer
• James Franklin Hyde (1903–1999), American chemist
• James F. C. Hyde (1825–1898), American politician from Massachusetts
• James Hazen Hyde (1876–1959), American businessman
• James M. Hyde (1873–1943), American metallurgist
• James S. Hyde (born 1932), American biophysicist