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"Although the cause of TS is unknown, current research points to abnormalities in certain brain regions (including the basal ganglia, frontal lobes, and cortex), the circuits that interconnect these regions, and the neurotransmitters (dopamine, serotonin, and norepinephrine) responsible for communication among nerve cells. Given the often complex presentation of TS, the cause of the disorder is likely to be equally complex."
This does not support the conclusion that the cause is "genetic with environmental influence." Brain abnormalities can be "genetic with environmental influence" or they could be enirely genetic or entirely environmental.
I propose the cause be changed to simply "unknown." There doesn't seem to be a consistent convention used across articles, but I have seen both "unknown" [2] and "inconclusive" [3] used to describe cause in the fact table. Mattjazar (talk) 19:42, 7 December 2025 (UTC)[reply]
Qi Y, Zheng Y, Li Z, Liu Z, Xiong L (2019). "Genetic Studies of Tic Disorders and Tourette Syndrome". Methods Mol Biol. 2011: 547–571. doi:10.1007/978-1-4939-9554-7_32. PMID31273721. Previous family and twin studies have shown that the majority of cases of TS are inherited. TS was previously thought to have an autosomal dominant pattern of inheritance. However, several decades of research have shown that this is unlikely the case. Instead, TS most likely results from a variety of genetic and environmental factors, not changes in a single gene.SandyGeorgia (Talk) 21:56, 7 December 2025 (UTC)[reply]