Esperanza is the Spanish word for hope, and may refer to:

• Esperanza, Agusan del Sur, a municipality
• Esperanza, Masbate, a municipality
• Esperanza, Sultan Kudarat, a municipality

• Esperanza, Mississippi, an unincorporated community
• Esperanza, New York, historic name of the village of Athens
• Esperanza, Hudspeth County, Texas, an unincorporated community
• Esperanza, Montgomery County, Texas, a ghost town
• Esperanza, Puerto Rico, a town in Vieques
• Esperanza (Jerusalem, New York), an historic home in Jerusalem, New York

• Esperanza Base, a settlement in Antarctica
• Esperanza, Santa Fe, a city in Argentina
• Esperanza, Belize, a village in Cayo District, Belize
• La Esperanza, Norte de Santander, Colombia, a municipality and town
• Esperanza (Ranchuelo), a village in Villa Clara Province, Cuba
• Esperanza, Dominican Republic, a municipality in Valverde province
• La Esperanza, Ecuador, a town and parish
• La Esperanza, Quetzaltenango, Guatemala, a municipality
• La Esperanza, Honduras, a city and municipality in Intibucá Department
• Esperanza (municipality), a town and municipality in Puebla, Mexico
• Esperanza, Ucayali, a city in Peru
• La Esperanza, the seat of the municipality of El Rosario, Tenerife, in the Canary Islands of Spain
• La Esperanza (prison), El Salvador

• Esperanza mine, underground copper mine in Atacama Region, Chile
• Esperanza mine which was merged in 2014 with El Tesoro mine to form the Centinela copper mine, Antofagasta Region, Chile
• Esperanza mine, a former silver mine in Chañarcillo, Atacama Region, Chile

• Esperanza (given name), a Spanish feminine given name, and people with that name
• Gabriel Esperanza, 17th-century rabbi

• Esperanza (film), a 1946 Mexican film
• Esperanza (Philippine TV series)
• Esperanza (Chilean TV series), a 2011 telenovela

• Esperanza, a flamenco project by Carlos Villalobos
• Esperanza (Michael Rother album), 1996
• Esperanza (Esperanza Spalding album), 2008
• Próxima Estación: Esperanza, a 2001 album by Manu Chao
• "Esperanza" (Charles Aznavour song), 1961
• "Esperanza" (Enrique Iglesias song), 1998

• Esperanza International, a non-profit organization that develops Dominican Republican communities through microfinancing
• Esperanza Peace and Justice Center, a non-profit community-based arts & cultural organization that advocates for social justice
• Esperanza Unida, Inc., a non-profit organization that provides job training and placement to unemployed minority workers in Milwaukee, Wisconsin, United States

• MV Esperanza, a 1984 Greenpeace ship
• Esperanza (Madrid Metro), a station of the Madrid Metro
• Esperanza (bug), a genus of bugs
• Tecoma stans, a yellow flower sometimes called esperanza
• Esperanza High School, Anaheim, California, United States
• Esperanza Drum and Bugle Corps, a modern drum corps from San Diego, California, United States
• Esperanza Ortega, the title character of Esperanza Rising, a 2000 novel
• La Esperanza Airport (Nicaragua)
• Esperanza Diamond, found in Crater of Diamonds State Park

• Esperanza Fire, a wind-driven arson fire that started in a river wash near Cabazon, California
• Esperança (disambiguation)
• Esperanto, the most widely spoken constructed international auxiliary language
• Teatro de la Ciudad, Mexico City, formerly Teatro Esperanza Iris