Juan Capistrano Sepúlveda (1814–1898) was a Californio politician and pioneer in Los Angeles. He was a member of the prominent Sepúlveda family of California.

Juan Capistrano Sepúlveda was a son of José Dolores Sepúlveda (1793 - 1824). He served on the third Los Angeles County Board of Supervisors in 1854 for the 3rd District.^[1] The County Supervisors in 1854 were David W. Alexander, Stephen C. Foster, Juan Sepúlveda, Cristóbal Aguilar, and Samuel S. Thompson.