Twitchell (also spelled Twichell) is a surname, and may refer to:

• Chase Twichell, American poet
• Jenny Twitchell Kempton (1835–1921), American operatic contralto
• Rev. Dr. Joseph Twichell, New England reverend, friend of Mark Twain
• Karl Twitchell, American engineer and surveyor
• Kent Twitchell, American artist
• Mark Twitchell, Canadian filmmaker convicted of murder
• Marshall H. Twitchell, Louisiana state senator and carpetbagger during the Reconstruction Era in the United States
• Paul Twitchell, American religious leader
• Ralph Twitchell, American architect
• Wayne Twitchell, American baseball player

• Twitchell Reservoir, in California
• Twitchell Creek, in New York
• Twitchell Lake (disambiguation)
• Twitchell Mountain, in New York
• Twitchett
• Twichell, a dialect term for an alley
• Commonwealth v. Twitchell
• The dictionary definition of twitchel at Wiktionary