Substitute may refer to:

• Substitute (film), a 2006 film by Vikash Dhorasoo
• The Substitute (1993 film), a telefilm by Martin Donovan
• The Substitute, a 1996 thriller film starring Tom Berenger
• The Substitute 2: School's Out, a 1998 action-crime-thriller starring Treat Williams
• The Substitute 3: Winner Takes All, a 1999 action thriller starring Treat Williams
• The Substitute: Failure Is Not an Option, a 2001 action thriller starring Treat Williams
• The Substitute (2007 film), a Danish science fiction horror film
• The Substitute (2015 film), a short film
• The Substitute (2022 film), a 2022 film directed by Diego Lerman

• Substitute (elections)

• "Substitute" (Beavis and Butt-head episode), an episode of Beavis and Butt-head
• "The Substitute" (Glee), a Glee episode
• "The Substitute" (Lost), an episode of Lost
• "The Substitute" (Recess episode), an episode of Recess
• The Substitute (Chinese TV series), a 2015 Chinese thriller television series released on iQIYI
• The Substitute (American TV series), a 2019 American television series on Nickelodeon

• "Substitute" (The Righteous Brothers song), 1975
• "Substitute" (The Who song), 1966
• The Substitute (soundtrack), the soundtrack to the 1996 crime film

• Substitute (association football)
• Substitute (cricket)
• Substitute good, in economics, a good that can be used instead of another
• Ersatz good, in economics, a substitute good, inferior in quality
• Substitute character, on keyboards, a control character used in the place of another character
• Substitute natural gas
• Substitute teacher, a temporary replacement in a teacher's absence

• All pages with titles beginning with Substitute
• All pages with titles containing Substitute
• Interchange (Australian rules football)
• Makeshift (disambiguation)
• Placeholder (disambiguation)
• Sub (disambiguation)
• Substitution (disambiguation)