Niche may refer to:

• Developmental niche, a concept for understanding the cultural context of child development
• Ecological niche, a term describing the relational position of an organism's species
• Niche differentiation, in ecology, the process by which competing species use the environment differently in a way that helps them to coexist
• Niche (protein structural motif)
• Stem-cell niche, the necessary cellular environment of a stem cell

• Niche market, a focused, targetable portion (subset) of a market sector
  • Niche blogging, a blog focused on a niche market

• Bassline (music genre), a type of music related to UK garage also called Niche
• Niche (architecture), an exedra or an apse that has been reduced in size
  • A cell of a columbarium for a cremation urn
• Niche (company), an Internet search and review service
• Niche (horse), a British Thoroughbred racehorse
• Niche (video game), a 2017 video game
• Niche, a character in the manga Tegami Bachi
• Niche (footballer), Bissau-Guinean footballer
• Network in Canadian History and Environment, a group of Canadian environmental historians
• Nishe, a B-Side from the 2000 single Unintended by English rock band, Muse