Mohammad Yusuf, Muhammad Yousuf and other spellings, may refer to:

• Mohammad Yusuf (politician), prime minister and foreign minister of Afghanistan
• Mohammad Yousef (politician), a governor of Daykundi province, Afghanistan
• Muhammad Yusuf Abdullah Haroon (1916–2011), politician from Sindh, Pakistan
• Mohamed Yusuf Haji (born 1940), Somali politician and Kenyan Member of Parliament

• Mohamed Yusuf (athlete) (born 1968), Indonesian Olympic sprinter
• Mohammad Yousuf (cricketer) born 1974), Pakistani international cricketer
• Muhammad Yousaf (snooker player), Pakistani snooker player

• Mohammed Yusuf (Boko Haram) (1970–2009), Nigerian sect leader of Boko Haram
• Mohamed Yusuf (1876–1965), Indian businessman
• Mohammad Yousuf Azraq, Afghanistan historian and writer
• Muhammad Yusuf Kandhalawi (1917–1965), Indian Muslim scholar, leader of the Tablighi Jamaat
• Mohammad Yusuf Khan (disambiguation), several people, including:
  • Muhammad Yousuf Khan (1922–2021), also known as Dilip Kumar, Indian film actor
• Yusaf Khan (general), Muhammad Yusaf Khan, former Vice Chief of Pakistan Army Staff

• Muhammad (disambiguation)
• Muhammad (name)
• Yusuf