Isse or ISSE may refer to:
Places
Computing
- Information Systems Security Engineering
- Internet Streaming SIMD Extensions, an SIMD instruction set extension to the x86 architecture by Intel introduced in 1999
- Integer Streaming SIMD Extensions, an informal name for MMX extensions associated with 3DNow! extensions
Other uses
- Issé (opera), by André Cardinal Destouches
- International Secondary School Eindhoven, a school in the Netherlands
- International Students for Social Equality
- Hirsi Magan Isse (1935–2008), scholar and a leading figure of the Somali Revolution