Caffarelli may be
- Caffarelli (castrato), stage name of the castrato Gaetano Majorano (1710-1783)
- Carmela Cafarelli (1889-1979) was proprietor of Cleveland Ohio's Cafarelli Opera Company
- Luis Caffarelli (born 1948), Argentine mathematician
- A family of French church and military leaders, all of them brothers:
- Louis-Marie-Joseph Maximilian Caffarelli du Falga (1756-1799), general
- Charles Ambroise de Caffarelli du Falga (1758-1826), canon and prefect
- Louis Marie Joseph Caffarelli (1760-1845), the first préfet maritime de Brest
- Jean-Baptiste de Caffarelli du Falga (1763-1815), bishop of Saint-Brieuc
- Marie-François Auguste de Caffarelli du Falga (1766-1849), general
.